Table 2 Results from the non-inferiority assessment of PermaNet® Dual to Interceptor® G2 against wild pyrethroid-resistant An. funestus in experimental huts in Siaya, western Kenya
Primary indicators | Variables | PermaNet® 3.0 | PermaNet® Dual | Interceptor® G2 | PermaNet® Dual |
|---|---|---|---|---|---|
Total collected | 4390 | 4481 | 4036 | 4481 | |
Mortality | Total dead | 2441 | 3029 | 2629 | 3029 |
Observed mortality (%) | 56 | 68 | 65 | 68 | |
Corrected mortality (%) | 30.2 | 49.2 | 44.4 | 49.2 | |
Odds ratio | – | 2.246 | – | 1.211 | |
Std. error (on log odds scale) | – | 0.080 | – | 0.050 | |
P-value | – | < 0.001 | – | 0.047 | |
95% CIs | – | 1.920–2.627 | – | 1.097–1.337 | |
WHO efficacy criteria | – | Significantly higher (p < 0.05) | – | Lower 95% CI > 0.7 | |
Conclusion | – | Superior | – | Non-inferior | |
Blood feeding | Total blood-fed | 423 | 671 | 517 | 671 |
Blood-feeding (%) | 10 | 15 | 13 | 15 | |
Odds ratio | – | 1.627 | – | 1.176 | |
Std. error (on log odds scale) | – | 0.110 | – | 0.076 | |
P-value | – | < 0.001 | – | 0.012 | |
95% CIs | – | 1.425–1.856 | – | 1.037–1.334 | |
WHO efficacy criteria | – | Significantly lower (p < 0.05) | – | Upper 95% CI < 1.43 | |
Conclusion | – | Inferior | – | Inferior and non-inferior |