Fig. 6

Receiver-operator characteristic (ROC) curves of GHPB compounds tested in P. berghei and cytotoxicity assays. ROC curves indicate the sensitivity and specificity of an assay based on a range of inhibition values from the primary screen (grey circles). The red line indicates a random assay. A ROC curve for P. berghei using FLAR, AUC = 1.0 (95% CI 1.0–1.0). B) ROC curve for HepG2 cytotoxicity using galactose media, AUC = 0.8932 (95% CI 0.7465–1.000). AUCs were calculated using the Wilson/Brown method