Fig. 5

Results table, potencies, and structures of selective GHPB hits. A Table of pEC₅₀ values for GHPB compounds. pEC50 is the negative log of potency in M (ie a pEC₅₀ of 6 = an EC₅₀ of 1 µM and a pEC₅₀ of 9 = an EC₅₀ of 1 nM). Values are the average and S.D. from two independent experiments (runs). Anti-malarial potencies are grouped as selectively active, active but with low selectivity, and nonselective or inactive. B Dose–response charts and structures for active and selective hits. Bars represent S.E.M. of two replicate wells at each dose from each of two independent experiments charted together