Analysis No
| S | N | p |
Z
|
V
|
Z significant |
Z not significant |
|---|
-
| 0 | 0 | 0 | 0 | 0 | -2.58 | 2.58 |
1
| 1 | 2 | 0.50 | 0.10 | 0.50 | -2.83 | 1.83 |
2
| 2 | 4 | 0.50 | 0.20 | 0.99 | -3.07 | 1.08 |
3
| 3 | 5 | 0.60 |
0.75
| 1.24 | -3.20 |
0.71
|
- The trial was designed with the triangular test for p
0 = 0.45, p
a
= 0.12, α = 0.05, and β = 0.10. S denotes the number of relapses observed; N, the number of patients included; p, is the relapse rate; Z= S – N p
0; and V = N p
0 (1 - p
0). The setting of the triangular test is detailed in the text. At the third analysis, the Z value exceeded the upper boundary value (bolded in the table). At this time, the data indicate that the study should stop, and we can conclude that azithromycin treatment has not significantly reduced the relapse rate of P. vivax infection.
